Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction

被引：198
|
作者：
Dondoni, A [1 ]
Massi, A [1 ]
机构：
[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期
关键词：
Biginelli reaction; dihydropyrimidinones; polymer-supported reagents; multicomponent reaction;
D O I：
10.1016/S0040-4039(01)01728-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of an array of 3,4-dihydropyrimidin-2-(1H)-ones using solid-supported ytterbium(III) reagent from aldehydes, 1,3-dicarbonyl compounds and urea (Biginelli reaction) under solvent-free conditions is described. Purification of each member of the library was carried out using a cocktail of acid and basic polymer-supported scavengers (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7975 / 7978
页数：4
相关论文
共 50 条
  • [31] Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions
    Prajapati, Dipak
    Bhuyan, Debajyoti
    Gohain, Mukut
    Hu, Wenhao
    MOLECULAR DIVERSITY, 2011, 15 (01) : 257 - 261
  • [32] Green chemistry approaches to the regioselective synthesis of spiro heterobicyclic rings using iodine as a new and efficient catalyst under solvent-free conditions
    Dipak Prajapati
    Debajyoti Bhuyan
    Mukut Gohain
    Wenhao Hu
    Molecular Diversity, 2011, 15 : 257 - 261
  • [33] Bimetallic nanoparticles supported ionic liquid as an effective heterogeneous nanocatalyst for green synthesis of chromenes under solvent-free conditions
    Kazempour, Somayeh
    Naeimi, Hossein
    APPLIED ORGANOMETALLIC CHEMISTRY, 2022, 36 (12)
  • [34] A green approach for the synthesis of palladium nanoparticles supported on pectin: Application as a catalyst for solvent-free Mizoroki-Heck reaction
    Khazaei, Ardeshir
    Rahmati, Sadegh
    Hekmatian, Zahra
    Saeednia, Shahnaz
    JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2013, 372 : 160 - 166
  • [35] Green chemistry approach to synthesis of some new trifluoromethyl containing tetrahydropyrimidines under solvent free conditions
    Khunt, R. C.
    Akbari, J. D.
    Manvar, A. T.
    Tala, S. D.
    Dhaduk, M. F.
    Joshi, H. S.
    Shah, Anamik
    ARKIVOC, 2008, : 277 - U8
  • [36] Polymer-Supported Tribromide as a New Solid Phase and Recyclable Catalyst for the Synthesis of 2-(N-Arylamino) benzothiazoles Under Solvent-Free Microwave Irradiation Conditions
    Nahakpam, Lokendrajit
    Chingakham, Brajakishor S.
    Laitonjam, Warjeet S.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (01) : 267 - 272
  • [37] A green, practical & scalable approach towards the synthesis of valuable α-keto amides using a metal-free catalyst under solvent-free conditions
    Bankar, Shubham R.
    Ghadge, Sambhaji S.
    Jadhav, Vrushali H.
    NEW JOURNAL OF CHEMISTRY, 2023, 47 (42) : 19679 - 19687
  • [38] An Efficient Green Synthetic Approach to the Synthesis of 4H-Chromene Compounds under Solvent-free Conditions
    Zaki, Remon M.
    Metwally, Saoud A.
    Elossaily, Yasser A.
    Gaber, Taher A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (10) : 2417 - 2426
  • [39] Antimony(III) chloride impregnated on alumina - An efficient and economical Lewis acid catalyst for one-pot synthesis of dihydropyrimidinones under solvent-free conditions
    Kapoor, KK
    Ganai, BA
    Kumar, S
    Andotra, CS
    CANADIAN JOURNAL OF CHEMISTRY, 2006, 84 (03) : 433 - 437
  • [40] Polymer supported DMAP: an easily recyclable organocatalyst for highly atom-economical Henry reaction under solvent-free conditions
    Das, Diparjun
    Pathak, Gunindra
    Rokhum, Lalthazuala
    RSC ADVANCES, 2016, 6 (106): : 104154 - 104163
12345