Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction

被引：198
|
作者：
Dondoni, A [1 ]
Massi, A [1 ]
机构：
[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy
来源：
TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期
关键词：
Biginelli reaction; dihydropyrimidinones; polymer-supported reagents; multicomponent reaction;
D O I：
10.1016/S0040-4039(01)01728-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of an array of 3,4-dihydropyrimidin-2-(1H)-ones using solid-supported ytterbium(III) reagent from aldehydes, 1,3-dicarbonyl compounds and urea (Biginelli reaction) under solvent-free conditions is described. Purification of each member of the library was carried out using a cocktail of acid and basic polymer-supported scavengers (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7975 / 7978
页数：4
相关论文
共 50 条
  • [41] Magnesium Bromide and Magnesium Chloride Hexahydrate Catalyzed One-Pot Synthesis of Dihydropyrimidines via Biginelli Reaction under Solvent-Free Conditions
    Gulten, Sirin
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 391 - 395
  • [42] MICROWAVE-ASSISTED AND IODINE-CATALYZED SYNTHESIS OF DIHYDROPYRIMIDIN-2-THIONES VIA BIGINELLI REACTION UNDER SOLVENT-FREE CONDITIONS
    Liu, Qingjian
    Pan, Ning
    Xu, Jiehua
    Zhang, Wenwen
    Kong, Fanpeng
    SYNTHETIC COMMUNICATIONS, 2013, 43 (01) : 139 - 146
  • [43] Solvent-Free One-Pot Synthesis of Diverse Dihydropyrimidinones/Tetrahydropyrimidinones Using Biginelli Reaction Catalyzed by Fe3O4@C@OSO3H
    Taheri Hatkehlouei, Seyedeh Fatemeh
    Mirza, Behrooz
    Soleimani-Amiri, Somayeh
    POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (04) : 1341 - 1357
  • [44] Eggshell-supported-Cu(II) salophen complex: An efficient and green catalyst for synthesis of propargylamines under solvent-free conditions
    Bakherad, Mohammad
    Keivanloo, Ali
    Amin, Amir Hossein
    Doosti, Raheleh
    Hoseini, Ommolbanin
    IRANIAN JOURNAL OF CATALYSIS, 2016, 6 (04): : 325 - 332
  • [45] An efficient green protocol for the synthesis of chalcones by a Claisen-Schmidt reaction using bismuth(III)chloride as a catalyst under solvent-free condition
    Kumar, Dhruva
    Suresh
    Sandhu, Jagir S.
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2010, 3 (04) : 283 - 286
  • [46] Facile and green synthesis of triarylmethanes using silica sulfuric acid as a reusable catalyst under solvent-free conditions
    Mohammadpoor-Baltork, I.
    Moghadam, M.
    Tangestaninejad, S.
    Mirkhani, V.
    Mohammadiannejad-Abbasabadi, K.
    Zolfigol, M. A.
    COMPTES RENDUS CHIMIE, 2011, 14 (10) : 934 - 943
  • [47] An Efficient Biginelli One-Pot Synthesis of New Benzoxazole-Substituted Dihydropyrimidinones and Thiones Catalysed by Alumina-Supported Trifluoromethane Sulfonic Acid Under Solvent Free Conditions
    Arjun, M.
    Sridhar, D.
    Chari, M. Adharvana
    Sarangapani, M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 46 (01) : 119 - 123
  • [48] Gallic acid-functionalized magnetic nanoparticles: a convenient and green approach for synthesis of α-aminonitriles under solvent-free conditions
    Esmaiel Eidi
    Mohamad Z. Kassaee
    Zahra Nasresfahani
    Peter T. Cummings
    Research on Chemical Intermediates, 2019, 45 : 303 - 314
  • [49] Gallic acid-functionalized magnetic nanoparticles: a convenient and green approach for synthesis of -aminonitriles under solvent-free conditions
    Eidi, Esmaiel
    Kassaee, Mohamad Z.
    Nasresfahani, Zahra
    Cummings, Peter T.
    RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (02) : 303 - 314
  • [50] Gallium(III) Iodide-catalyzed Biginelli-type Reaction Under Solvent-free Conditions: Efficient Synthesis of Dihydropyrimidine-2(1H)-one Derivatives
    Li Dapeng
    Mao Haifeng
    An Litao
    Huang Zhihao
    Zou Jianping
    CHINESE JOURNAL OF CHEMISTRY, 2010, 28 (10) : 2025 - 2032
12345