Ultrasound-Assisted Slug-Flow Tubular Crystallization for Preparation of Fine Ibuprofen Crystals

被引：4

作者：

Yuan, Mingpu ^{[1
]}

Wang, Jingkang ^{[1
,2
]}

Huang, Xin ^{[1
,2
,3
]}

Wang, Ting ^{[1
,2
,3
]}

Wang, Na ^{[1
,2
,3
]}

Zhou, Lina ^{[1
,2
]}

Hao, Hongxun ^{[1
,2
,4
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, 92 Weijin Rd, Tianjin 300072, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Chem Engn, 92 Weijin Rd, Tianjin 300072, Peoples R China

[3] Tianjin Univ, Zhejiang Inst, Ningbo, Zhejiang, Peoples R China

[4] Hainan Univ, Sch Chem Engn & Technol, 58 Renmin Ave, Haikou 570208, Hainan, Peoples R China

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2022年 / 45卷 / 04期

关键词：

Continuous crystallization; Ibuprofen crystals; Slug-flow crystallization; Ultrasound; PARTICLE-SIZE; DESIGN; FORMULATION; DELIVERY; GROWTH;

D O I：

10.1002/ceat.202100574

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Ibuprofen fine crystals prepared by commonly used methods have some problems such as low-crystallinity product and uneven distributed particle size. An ultrasonic-assisted tubular crystallization system was developed. The effects of tubular crystallization temperature, supersaturation, residence time, surfactant, and flow pattern on the crystal size distribution and average particle size were studied. It was found that ultrasound promotes nucleation and reduces crystal aggregation. Ibuprofen crystals with an average particle size of 6.23 mu m were formed owing to the high degree of continuous supersaturation and promoted micromixing. Finally, a possible mechanism of enhancement of micromixing under ultrasonic and slug flow on tubular crystallization was proposed.

引用

页码：727 / 736

页数：10

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