Ultrasound-Assisted Slug-Flow Tubular Crystallization for Preparation of Fine Ibuprofen Crystals

被引：7
|
作者：
Yuan, Mingpu [1 ]
Wang, Jingkang [1 ,2 ]
Huang, Xin [1 ,2 ,3 ]
Wang, Ting [1 ,2 ,3 ]
Wang, Na [1 ,2 ,3 ]
Zhou, Lina [1 ,2 ]
Hao, Hongxun [1 ,2 ,4 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, 92 Weijin Rd, Tianjin 300072, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Chem Engn, 92 Weijin Rd, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Zhejiang Inst, Ningbo, Zhejiang, Peoples R China
[4] Hainan Univ, Sch Chem Engn & Technol, 58 Renmin Ave, Haikou 570208, Hainan, Peoples R China
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2022年 / 45卷 / 04期
关键词：
Continuous crystallization; Ibuprofen crystals; Slug-flow crystallization; Ultrasound; PARTICLE-SIZE; DESIGN; FORMULATION; DELIVERY; GROWTH;
D O I：
10.1002/ceat.202100574
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Ibuprofen fine crystals prepared by commonly used methods have some problems such as low-crystallinity product and uneven distributed particle size. An ultrasonic-assisted tubular crystallization system was developed. The effects of tubular crystallization temperature, supersaturation, residence time, surfactant, and flow pattern on the crystal size distribution and average particle size were studied. It was found that ultrasound promotes nucleation and reduces crystal aggregation. Ibuprofen crystals with an average particle size of 6.23 mu m were formed owing to the high degree of continuous supersaturation and promoted micromixing. Finally, a possible mechanism of enhancement of micromixing under ultrasonic and slug flow on tubular crystallization was proposed.
引用
收藏
页码：727 / 736
页数：10
相关论文
共 50 条
  • [21] Ultrasound-assisted click chemistry in continuous flow
    Noah P. Tu
    Jill E. Hochlowski
    Stevan W. Djuric
    Molecular Diversity, 2012, 16 : 53 - 58
  • [22] Enantioselective synthesis of (-)-(R) Silodosin by ultrasound-assisted diastereomeric crystallization
    Barve, Indrajeet J.
    Chen, Li-Hsun
    Wei, Patrick C. P.
    Hung, Jui-Te
    Sun, Chung-Ming
    TETRAHEDRON, 2013, 69 (13) : 2834 - 2843
  • [23] Ultrasound-assisted cooling crystallization of ciprofloxacin using ultrasonic horn
    Hirpara, Yagna S.
    Gogate, Parag R.
    CHEMICAL PAPERS, 2024, 78 (11) : 6483 - 6498
  • [24] Ultrasound-assisted crystallization of lactose in the presence of whey proteins and κ-carrageenan
    Sanchez-Garcia, Yanira I.
    Garcia-Vega, Karen S.
    Leal-Ramos, Martha Y.
    Salmeron, Ivan
    Gutierrez-Mendez, Nestor
    ULTRASONICS SONOCHEMISTRY, 2018, 42 : 714 - 722
  • [25] Preparation of astaxanthin by lipase-catalyzed hydrolysis from its esters in a slug-flow microchannel reactor
    Mei, Jianfeng
    Zhao, Xiaoyun
    Yi, Yu
    Zhang, Yanlu
    Wang, Xudong
    Ying, Guoqing
    PROCESS BIOCHEMISTRY, 2020, 98 : 241 - 246
  • [26] Ultrasound-Assisted Preparation and Performance Regulation of Electrocatalytic Materials
    Deng, Qibo
    Chen, Shuang
    Wu, Wenliu
    Zhang, Shiyu
    An, Cuihua
    Hu, Ning
    Han, Xiaopeng
    CHEMPLUSCHEM, 2024, 89 (05):
  • [27] Investigation of conditions for ultrasound-assisted preparation of nickel ferrite
    L. A. Frolova
    A. A. Pivovarov
    High Energy Chemistry, 2015, 49 : 10 - 15
  • [28] Preparation of Ag nanoparticles by ultrasound-assisted membrane reaction
    Wang Zhen-Yang
    Guan Xiao
    He Hong
    Dai Hong-Xing
    Zi Xue-Hong
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2007, 28 (09): : 1756 - 1758
  • [29] Ultrasound-assisted preparation of calcium malate and its absorption
    Ma, Wuren
    Lv, Yizhou
    Cao, Xuan
    Wang, Mengzhi
    Fan, Yunpeng
    Shan, Yuanyuan
    PLOS ONE, 2021, 16 (07):
  • [30] Preparation of Ag nanoparticles by ultrasound-assisted membrane reaction
    Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100022, China
    Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao, 2007, 9 (1756-1758):
12345