Synthesis of novel phosphoramide-tegafur derivatives containing aminopropylsilatrane

被引：6
|
作者：
Shi, DQ [1 ]
Chen, Q [1 ]
Li, ZH [1 ]
Liu, XP [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2005年 / 180卷 / 07期
关键词：
anti-tumor activity; gamma-aminopropyl silatrane; phosphoramide; tegafur;
D O I：
10.1080/104265090885039
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of novel phosphoramide-tegafur derivatives containing gamma-aminopropyl silatrane were synthesized Via the condensation reactions of phosphoryl dichloride with N-1-(2-furanidyl)-N-3-(hydroxyethyl)-5-fluorouracil, followed by condensation with gamma-aminopropyl silatrane. The structures of the products were confirmed by H-1 NMR, P-31 NMR, IR, MS, and elemental analysis. The results of preliminary bioassay showed that the new compounds had an inhibition effect against HCT-8 and Bel-7402 cell lines.
引用
收藏
页码：1621 / 1627
页数：7
相关论文
共 50 条
  • [41] A Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone
    Yuan, Jinwei
    Chen, Xiaolan
    Qu, Lingbo
    Zhang, Shouren
    Lu, Jiansha
    Zhao, Yufen
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (11) : 2936 - 2944
  • [42] Synthesis, X-ray Crystallography, and DFT Calculations of A Novel Phosphoramide
    Shariatinia, Zahra
    Dusek, Michal
    Eigner, Vaclav
    ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 2014, 640 (14): : 2945 - 2955
  • [43] Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies
    Mei, Haoran
    Wang, Na
    Wu, Di
    Rong, Qi
    Bai, Xue
    Huang, Xin
    Zhou, Lina
    Wang, Ting
    Hao, Hongxun
    PHARMACEUTICAL RESEARCH, 2024, 41 (03) : 577 - 593
  • [44] Novel Pharmaceutical Cocrystals of Tegafur: Synthesis, Performance, and Theoretical Studies
    Haoran Mei
    Na Wang
    Di Wu
    Qi Rong
    Xue Bai
    Xin Huang
    Lina Zhou
    Ting Wang
    Hongxun Hao
    Pharmaceutical Research, 2024, 41 : 577 - 593
  • [45] SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SOME NEW PIPERAZINE PHOSPHORAMIDE DERIVATIVES OF 4-HYDROXYCOUMARIN
    Chen, Xiaolan
    Yuan, Jinwei
    Qu, Lingbo
    Qu, Zhibo
    Xu, Shaohua
    Wang, Fujun
    Zhao, Yufen
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2012, 187 (02) : 245 - 254
  • [46] Synthesis and insecticidal activity of novel benzothiazole derivatives containing the coumarin moiety
    Si, Wei-Jie
    Chen, Min
    Wang, Xue-Lun
    Wang, Meng-Qi
    Jiao, Jian
    Fu, Xin-Can
    Yang, Chun-Long
    ARKIVOC, 2018, : 86 - 99
  • [47] Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety
    Wang, Yan-Jiao
    Zhou, Da-Gui
    He, Fang-Cheng
    Chen, Ji-Xiang
    Chen, Yong-Zhong
    Gan, Xiu-Hai
    Hu, De-Yu
    Song, Bao-An
    CHINESE CHEMICAL LETTERS, 2018, 29 (01) : 127 - 130
  • [48] SYNTHESIS AND CHARACTERISTICS OF NOVEL OLIGONUCLEOTIDE DERIVATIVES CONTAINING REACTIVE UREIDO GROUPS
    IVANOVSKAYA, MG
    NARYSHKIN, NA
    SHABAROVA, ZA
    BIOORGANICHESKAYA KHIMIYA, 1995, 21 (06): : 454 - 460
  • [49] Synthesis and antiviral bioactivity of novel chalcone derivatives containing purine moiety
    Yan-Jiao Wang
    Da-Gui Zhou
    Fang-Cheng He
    Ji-Xiang Chen
    Yong-Zhong Chen
    Xiu-Hai Gan
    De-Yu Hu
    Bao-An Song
    ChineseChemicalLetters, 2018, 29 (01) : 127 - 130
  • [50] Synthesis and antifungal activity of novel pyrazolecarboxamide derivatives containing a hydrazone moiety
    Wu, Jian
    Wang, Jian
    Hu, Deyu
    He, Ming
    Jin, Linhong
    Song, Baoan
    CHEMISTRY CENTRAL JOURNAL, 2012, 6
12345