Synthesis of novel phosphoramide-tegafur derivatives containing aminopropylsilatrane

被引：6

作者：

Shi, DQ ^{[1
]}

Chen, Q ^{[1
]}

Li, ZH ^{[1
]}

Liu, XP ^{[1
]}

机构：

[1] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2005年 / 180卷 / 07期

关键词：

anti-tumor activity; gamma-aminopropyl silatrane; phosphoramide; tegafur;

D O I：

10.1080/104265090885039

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel phosphoramide-tegafur derivatives containing gamma-aminopropyl silatrane were synthesized Via the condensation reactions of phosphoryl dichloride with N-1-(2-furanidyl)-N-3-(hydroxyethyl)-5-fluorouracil, followed by condensation with gamma-aminopropyl silatrane. The structures of the products were confirmed by H-1 NMR, P-31 NMR, IR, MS, and elemental analysis. The results of preliminary bioassay showed that the new compounds had an inhibition effect against HCT-8 and Bel-7402 cell lines.

引用

页码：1621 / 1627

页数：7

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