A Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone

被引：1
|
作者：
Yuan, Jinwei [1 ]
Chen, Xiaolan [1 ]
Qu, Lingbo [1 ,2 ]
Zhang, Shouren [1 ]
Lu, Jiansha [1 ]
Zhao, Yufen [1 ,3 ]
机构：
[1] Zhengzhou Univ, Dept Chem, Key Lab Organ Chem & Chem Biol, Zhengzhou 450052, Henan Province, Peoples R China
[2] Henan Univ Technol, Zhengzhou 450000, Henan Province, Peoples R China
[3] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ,Sch Life Sci & Engn, Beijing 100084, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 11期
关键词：
Amino acid ester; 2-arylquinolone; phosphoramide mustard; ANTITUMOR AGENTS; 2-PHENYL-4-QUINOLONES; CYTOTOXICITY; DERIVATIVES; TUBULIN;
D O I：
10.1080/10426500802625529
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of novel phosphoramide mustard analogues of 2-arylquinolones are synthesized through a convenient and facile phosphorylated reaction, and their structures are elucidated by NMR, IR, and HR MS. The amino acid esters and phosphoryl nitrogen mustard are linked to 2-arylquinolone to improve their undesirable physicochemical and biological properties.
引用
收藏
页码：2936 / 2944
页数：9
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