A Convenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-Arylquinolone

被引：1

作者：

Yuan, Jinwei ^{[1
]}

Chen, Xiaolan ^{[1
]}

Qu, Lingbo ^{[1
,2
]}

Zhang, Shouren ^{[1
]}

Lu, Jiansha ^{[1
]}

Zhao, Yufen ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Key Lab Organ Chem & Chem Biol, Zhengzhou 450052, Henan Province, Peoples R China

[2] Henan Univ Technol, Zhengzhou 450000, Henan Province, Peoples R China

[3] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ,Sch Life Sci & Engn, Beijing 100084, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2009年 / 184卷 / 11期

关键词：

Amino acid ester; 2-arylquinolone; phosphoramide mustard; ANTITUMOR AGENTS; 2-PHENYL-4-QUINOLONES; CYTOTOXICITY; DERIVATIVES; TUBULIN;

D O I：

10.1080/10426500802625529

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of novel phosphoramide mustard analogues of 2-arylquinolones are synthesized through a convenient and facile phosphorylated reaction, and their structures are elucidated by NMR, IR, and HR MS. The amino acid esters and phosphoryl nitrogen mustard are linked to 2-arylquinolone to improve their undesirable physicochemical and biological properties.

引用

页码：2936 / 2944

页数：9

共 50 条

[21] Design and synthesis of peptide conjugates of phosphoramide mustard as prodrugs activated by prostate-specific antigen
Wu, Xinghua
Hu, Longqin
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (12) : 2697 - 2706
[22] Convenient synthesis and diversification of dehydroalaninyl phosphinic peptide analogues
Matziari, M
Georgiadis, D
Dive, V
Yiotakis, A
ORGANIC LETTERS, 2001, 3 (05) : 659 - 662
[23] Novel Sophoridine Derivatives Bearing Phosphoramide Mustard Moiety Exhibit Potent Antitumor Activities In Vitro and In Vivo
Li, Dongdong
Dai, Linlin
Zhao, Xiumei
Zhi, Shuang
Shen, Hongsheng
Yang, Zibo
MOLECULES, 2018, 23 (08)
[24] Synthesis of novel phosphoramide-tegafur derivatives containing aminopropylsilatrane
Shi, DQ
Chen, Q
Li, ZH
Liu, XP
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (07) : 1621 - 1627
[25] Design, Synthesis, and Biological Evaluation of Artemisinin-Piperazine-Phosphoramide Mustard Hybrids as Potential Anticancer Agents
Wei, Meng-Xue
Zhang, Si-Si
Sun, Xuanrong
Ji, Yang
Yang, Pei-Wen
Li, Xue-Qiang
CHEMMEDCHEM, 2022, 17 (17)
[26] Novel convenient synthesis of mitiglinide
Huang, Wei
Cen, Jun-Da
SYNTHETIC COMMUNICATIONS, 2007, 37 (13) : 2153 - 2157
[27] Novel Convenient Synthesis of Rivastigmine
Hu, Meng
Zhang, Fu-Li
Xie, Mei-Hua
SYNTHETIC COMMUNICATIONS, 2009, 39 (09) : 1527 - 1533
[28] NOVEL AND CONVENIENT SYNTHESIS OF DIOXAPHOSPHOLES
SINGH, MS
MEHROTRA, KN
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1988, 61 (05) : 1795 - 1796
[29] A novel convenient synthesis of benzoquinazolines
Marzaro, G
Chilin, A
Pastorini, G
Guiotto, A
ORGANIC LETTERS, 2006, 8 (02) : 255 - 256
[30] A NOVEL CONVENIENT SYNTHESIS OF SELENOSULFONATES
WANG, L
HUANG, X
SYNTHETIC COMMUNICATIONS, 1993, 23 (20) : 2817 - 2820

← 1 2 3 4 5 →