Synthesis of novel phosphoramide-tegafur derivatives containing aminopropylsilatrane

被引：6
|
作者：
Shi, DQ [1 ]
Chen, Q [1 ]
Li, ZH [1 ]
Liu, XP [1 ]
机构：
[1] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2005年 / 180卷 / 07期
关键词：
anti-tumor activity; gamma-aminopropyl silatrane; phosphoramide; tegafur;
D O I：
10.1080/104265090885039
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of novel phosphoramide-tegafur derivatives containing gamma-aminopropyl silatrane were synthesized Via the condensation reactions of phosphoryl dichloride with N-1-(2-furanidyl)-N-3-(hydroxyethyl)-5-fluorouracil, followed by condensation with gamma-aminopropyl silatrane. The structures of the products were confirmed by H-1 NMR, P-31 NMR, IR, MS, and elemental analysis. The results of preliminary bioassay showed that the new compounds had an inhibition effect against HCT-8 and Bel-7402 cell lines.
引用
收藏
页码：1621 / 1627
页数：7
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