T Cell Help to B Cells in Germinal Centers: Putting the Jigsaw Together

被引：17

作者：

Gowthaman, Uthaman ^{[1
]}

Chodisetti, Sathi Babu ^{[1
]}

Agrewala, Javed N. ^{[1
]}

机构：

[1] Inst Microbial Technol, Council Sci Res, Constituent Lab, Chandigarh 160036, India

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 04期

关键词：

follicular T helper cells; B cells; germinal centers; T cell subsets; CLASS SWITCH RECOMBINATION; CXC CHEMOKINE RECEPTOR-5; IMMUNOGLOBULIN PRODUCTION; SYSTEMIC AUTOIMMUNITY; ANTIBODY-RESPONSES; CD40; LIGAND; DIFFERENTIATION; ANTIGEN; IL-21; ACTIVATION;

D O I：

10.3109/08830185.2010.496503

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.

引用

页码：403 / 420

页数：18

共 50 条

[41] GERMINAL-CENTERS AND THE ONTOGENY OF THE B-CELL SYSTEM
NIEUWENHUIS, P
GASTKEMPER, NA
HESSELINKVANDERHEIJDEN, D
MUGOPSTELTEN, D
ACTA MORPHOLOGICA NEERLANDO-SCANDINAVICA, 1981, 19 (01) : 63 - 63
[42] B cell recruitment and selection in mouse GALT germinal centers
Casola, S.
Rajewsky, K.
GUT-ASSOCIATED LYMPHOID TISSUES, 2006, 308 : 155 - 171
[43] SURFACE PHENOTYPE OF PEYERS PATCH GERMINAL CENTER CELLS - IMPLICATIONS FOR THE ROLE OF GERMINAL-CENTERS IN B-CELL DIFFERENTIATION
BUTCHER, EC
ROUSE, RV
COFFMAN, RL
NOTTENBURG, CN
HARDY, RR
WEISSMAN, IL
JOURNAL OF IMMUNOLOGY, 1982, 129 (06): : 2698 - 2707
[44] Surface phenotype of Peyer's patch germinal center cells: Implications for the role of germinal centers in B cell differentiation (Reprinted)
Butcher, EC
Rouse, RV
Coffman, RL
Nottenburg, CN
Hardy, RR
Weissman, IL
JOURNAL OF IMMUNOLOGY, 2005, 175 (03): : 1363 - 1372
[45] T follicular helper cells in germinal center B cell selection and lymphomagenesis
Mintz, Michelle A.
Cyster, Jason G.
IMMUNOLOGICAL REVIEWS, 2020, 296 (01) : 48 - 61
[46] Antigen valency dictates the affinity of B cells recruited to germinal centers and the magnitude of extrafollicular B cell responses
Kato, Yu
Groschel, Bettina
Abbott, Robert K.
Menis, Sergey
Irvine, Darrell J.
Schief, William R.
Crotty, Shane
JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
[47] The origin of T cell help for autoreactive B cells in SLE
Wysocki, LJ
Zhang, XH
Guth, A
Smith, DS
ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S62 - S62
[48] GERMINAL-CENTERS AND THE B-CELL SYSTEM .3. GERMINAL CENTER FORMING CAPACITY OF RABBIT APPENDIX GERMINAL CENTER (-DERIVED) CELLS
VANDERHEIJDEN, D
NIEWEG, O
RIJKMANS, B
STIKKER, R
OPSTELTEN, D
NIEUWENHUIS, P
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1980, 34 (01) : 43 - 52
[49] Dissecting the contribution of antigen-dependent B cell receptor engagement and T cell help to Germinal Center B cell selection and differentiation
Grigorova, Irina
Turner, Jackson S.
JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
[50] Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice
Yang, XH
Stedra, J
Cerny, J
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03): : 959 - 970

← 1 2 3 4 5 →