T Cell Help to B Cells in Germinal Centers: Putting the Jigsaw Together

被引：17

作者：

Gowthaman, Uthaman ^{[1
]}

Chodisetti, Sathi Babu ^{[1
]}

Agrewala, Javed N. ^{[1
]}

机构：

[1] Inst Microbial Technol, Council Sci Res, Constituent Lab, Chandigarh 160036, India

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2010年 / 29卷 / 04期

关键词：

follicular T helper cells; B cells; germinal centers; T cell subsets; CLASS SWITCH RECOMBINATION; CXC CHEMOKINE RECEPTOR-5; IMMUNOGLOBULIN PRODUCTION; SYSTEMIC AUTOIMMUNITY; ANTIBODY-RESPONSES; CD40; LIGAND; DIFFERENTIATION; ANTIGEN; IL-21; ACTIVATION;

D O I：

10.3109/08830185.2010.496503

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The germinal center (GC) reaction supports the processes of affinity maturation and class switching in B cells that result in long-lasting humoral immunity. CD4(+) T follicular helper cells (Tfh) participate in the GC reaction to help B cells. However, recent studies highlight the heterogeneity of CD4(+) T cells in GCs, which confounds the understanding of Tfh cells. Based on many recent studies, we have tried to form a working model on the niche of Tfh cells in GCs. We have also addressed whether Tfh cells are a distinct lineage and how they may be generated to help B cells.

引用

页码：403 / 420

页数：18

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