The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway

被引：11

作者：

Pan, You-lu ^{[1
]}

Gong, Xiao-meng ^{[1
]}

Hao, Rong-rong ^{[2
]}

Zeng, Shen-xin ^{[1
]}

Shen, Zheng-rong ^{[1
]}

Huang, Wen-hai ^{[1
]}

机构：

[1] Hangzhou Med Coll, Key Lab Neuropsychiat Drug Res Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[2] Hangzhou Chinese Acad Sci, Hangzhou Med Coll, Adv Med Technol Inst, Hangzhou, Zhejiang, Peoples R China

来源：

RSC ADVANCES | 2022年 / 12卷 / 16期

关键词：

INDOLE ALKALOIDS; SULFONYLATION/CYCLIZATION; 1,6-ENYNES; ACIDS;

D O I：

10.1039/d1ra06981k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile CuBr2 induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.

引用

页码：9763 / 9772

页数：10

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