The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway

被引：11
|
作者：
Pan, You-lu [1 ]
Gong, Xiao-meng [1 ]
Hao, Rong-rong [2 ]
Zeng, Shen-xin [1 ]
Shen, Zheng-rong [1 ]
Huang, Wen-hai [1 ]
机构：
[1] Hangzhou Med Coll, Key Lab Neuropsychiat Drug Res Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Chinese Acad Sci, Hangzhou Med Coll, Adv Med Technol Inst, Hangzhou, Zhejiang, Peoples R China
来源：
RSC ADVANCES | 2022年 / 12卷 / 16期
关键词：
INDOLE ALKALOIDS; SULFONYLATION/CYCLIZATION; 1,6-ENYNES; ACIDS;
D O I：
10.1039/d1ra06981k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile CuBr2 induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.
引用
收藏
页码：9763 / 9772
页数：10
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