Electrochemical Radical Tandem Difluoroethylation/Cyclization of Unsaturated Amides to Access MeCF2-Featured Indolo/Benzoimidazo [2,1-a]Isoquinolin-6(5H)-ones

被引：0
|
作者：
Tian, Yunfei [1 ]
Guo, Dongyu [2 ]
Zheng, Luping [1 ]
Yang, Shaolu [1 ]
Zhang, Ningning [1 ]
Fu, Weijun [1 ]
Li, Zejiang [2 ]
机构：
[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Key Lab Fuct Oriented Porous Mat Henan Prov, Luoyang 471934, Peoples R China
[2] Hebei Univ, Coll Chem & Mat Sci, Key Lab Med Chem & Mol Diag, Minist Educ,State Key Lab New Pharmaceut Preparat, Baoding 071002, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 05期
基金：
中国国家自然科学基金;
关键词：
electrochemical synthesis; difluoroethylation; radical; polycyclic compounds; tandem cyclization; INHIBITORS; FLUORINE; RECEPTOR;
D O I：
10.3390/molecules29050973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A metal-free electrochemical oxidative difluoroethylation of 2-arylbenzimidazoles was accomplished, which provided an efficient strategy for the synthesis of MeCF2-containing benzo[4,5]imidazo[2,1-a]-isoquinolin-6(5H)-ones. In addition, the method also enabled the efficient construction of various difluoroethylated indolo[2,1-a]isoquinolin-6(5H)-ones. Notably, this electrochemical synthesis protocol proceeded well under mild conditions without metal catalysts or exogenous additives/oxidants added.
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页数：15
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