Electrochemical Radical Tandem Difluoroethylation/Cyclization of Unsaturated Amides to Access MeCF2-Featured Indolo/Benzoimidazo [2,1-a]Isoquinolin-6(5H)-ones

被引：0

作者：

Tian, Yunfei ^{[1
]}

Guo, Dongyu ^{[2
]}

Zheng, Luping ^{[1
]}

Yang, Shaolu ^{[1
]}

Zhang, Ningning ^{[1
]}

Fu, Weijun ^{[1
]}

Li, Zejiang ^{[2
]}

机构：

[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Key Lab Fuct Oriented Porous Mat Henan Prov, Luoyang 471934, Peoples R China

[2] Hebei Univ, Coll Chem & Mat Sci, Key Lab Med Chem & Mol Diag, Minist Educ,State Key Lab New Pharmaceut Preparat, Baoding 071002, Peoples R China

来源：

MOLECULES | 2024年 / 29卷 / 05期

基金：

中国国家自然科学基金;

关键词：

electrochemical synthesis; difluoroethylation; radical; polycyclic compounds; tandem cyclization; INHIBITORS; FLUORINE; RECEPTOR;

D O I：

10.3390/molecules29050973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A metal-free electrochemical oxidative difluoroethylation of 2-arylbenzimidazoles was accomplished, which provided an efficient strategy for the synthesis of MeCF2-containing benzo[4,5]imidazo[2,1-a]-isoquinolin-6(5H)-ones. In addition, the method also enabled the efficient construction of various difluoroethylated indolo[2,1-a]isoquinolin-6(5H)-ones. Notably, this electrochemical synthesis protocol proceeded well under mild conditions without metal catalysts or exogenous additives/oxidants added.

引用

页数：15

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