Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

被引：4
|
作者：
Paidi, Karuna Raman [1 ]
Kolli, Murali Krishna [1 ]
Reddy, Eeda Koti [2 ]
Pedakotla, Venkata Ramana [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Anantapur 515003, Andhra Pradesh, India
[2] Vignans Fdn Sci Technol & Res Deemed Be Univ, Guntur Tenali Rd, Vadlamudi 522213, Andhra Pradesh, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 03期
关键词：
N-acylhydrazone; aldehyde; hydrazide; oxadiazole; sodium hypochlorite; oxidative cyclization; ONE-POT SYNTHESIS; OXIDATIVE CYCLIZATION; SUBSTITUTED 1,3,4-OXADIAZOLES; FUNGICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; ACID HYDRAZIDES; GREEN SYNTHESIS; OXADIAZOLE; DERIVATIVES; DESIGN;
D O I：
10.1007/s10593-020-02669-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.
引用
收藏
页码：371 / 376
页数：6
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