Synthesis and biological activity of some 2,5-disubstituted 1,3,4-oxadiazoles

被引：0
|
作者：
Alam, O [1 ]
Gupta, SK [1 ]
Imran, M [1 ]
Khan, SA [1 ]
机构：
[1] Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2005年 / 17卷 / 02期
关键词：
1,3,4-oxadiazoles; coumarin; antimicrobial activity; analgesic activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some new 2-(coumarin-3-yl)-5-aryl-1,3,4-oxadiazoles (IIIa-h) were synthesized by reacting hydrazide II of 3-carbethoxycoumarin (1) with various aromatic acids in presence of phosphorus oxychloride. Their elemental, IR and H-1 NMR data characterized these oxadiazoles. All the compounds were tested for their analgesic and antimicrobial activity against S. aureus, E. coli and C. albicans. Compounds IIIb, IIIc and IIIf exhibited interesting results.
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收藏
页码：1281 / 1286
页数：6
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