Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

被引：3
|
作者：
Paidi, Karuna Raman [1 ]
Kolli, Murali Krishna [1 ]
Reddy, Eeda Koti [2 ]
Pedakotla, Venkata Ramana [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Anantapur 515003, Andhra Pradesh, India
[2] Vignans Fdn Sci Technol & Res Deemed Be Univ, Guntur Tenali Rd, Vadlamudi 522213, Andhra Pradesh, India
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 03期
关键词：
N-acylhydrazone; aldehyde; hydrazide; oxadiazole; sodium hypochlorite; oxidative cyclization; ONE-POT SYNTHESIS; OXIDATIVE CYCLIZATION; SUBSTITUTED 1,3,4-OXADIAZOLES; FUNGICIDAL ACTIVITY; BIOLOGICAL-ACTIVITY; ACID HYDRAZIDES; GREEN SYNTHESIS; OXADIAZOLE; DERIVATIVES; DESIGN;
D O I：
10.1007/s10593-020-02669-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.
引用
收藏
页码：371 / 376
页数：6
相关论文
共 50 条
  • [31] BIOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF SYMMETRICAL 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES
    SHARMA, BL
    TANDON, SK
    [J]. PHARMAZIE, 1984, 39 (12): : 858 - 859
  • [32] Synthesis and evaluation of in vitro antioxidant properties of novel 2,5-disubstituted 1,3,4-oxadiazoles
    V. Lakshmi Ranganatha
    Shaukath Ara Khanum
    [J]. Russian Journal of Bioorganic Chemistry, 2014, 40 : 206 - 213
  • [33] Syntheses and insecticidal activities of novel 2,5-disubstituted 1,3,4-oxadiazoles
    Zheng, XM
    Li, Z
    Wang, YL
    Chen, WD
    Huang, QC
    Liu, CX
    Song, GH
    [J]. JOURNAL OF FLUORINE CHEMISTRY, 2003, 123 (02) : 163 - 169
  • [34] Synthesis and Evaluation of in vitro Antioxidant Properties of Novel 2,5-Disubstituted 1,3,4-Oxadiazoles
    Ranganatha, Lakshmi, V
    Khanum, Shaukath Ara
    [J]. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (02) : 206 - 213
  • [35] A NEW ACCESS TO UNSYMMETRICAL 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES AND 1,3,4-THIADIAZOLES
    POCHAT, F
    [J]. SYNTHESIS-STUTTGART, 1984, (02): : 146 - 148
  • [36] A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles
    Dabiri, Minoo
    Salehi, Peyman
    Baghbanzadeh, Mostafa
    [J]. TETRAHEDRON LETTERS, 2006, 47 (39) : 6983 - 6986
  • [37] Progress in the study on the synthesis and the activities as insect growth regulators of 2,5-disubstituted 1,3,4-oxadiazoles
    Cui, Zi-Ning
    Yang, Lin
    Li, Xi-Chen
    Wang, Zhen
    Yang, Xin-Lin
    [J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2006, 26 (12) : 1647 - 1656
  • [38] Microwave assisted one-pot synthesis of some 2,5-disubstituted 1,3,4-oxadiazoles
    Kalluraya, B.
    Rao, Jyothi N.
    Sujith, K. V.
    [J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2008, 17 (04) : 359 - 362
  • [39] A Novel Series of 2,5-Disubstituted 1,3,4-oxadiazoles: Synthesis and SAR Study for their Anticonvulsant Activity
    Rajak, Harish
    Singour, Pradeep
    Kharya, Murli Dhar
    Mishra, Pradeep
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2011, 77 (02) : 152 - 158
  • [40] PREPARATION OF 2-DISUBSTITUTED AND 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES FROM TETRAZOLES AND CARBOXYLIC-ACIDS
    POVAZANEC, F
    KOVAC, J
    SVOBODA, J
    [J]. COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1980, 45 (04) : 1299 - 1300
12345