A FACILE SYNTHESIS OF NOVEL HETEROCYCLIC COMPOUNDS WITH ANTICIPATED ANTIBACTERIAL ACTIVITIES BASED ON COUMARIN MOIETY

被引：9

作者：

Mourad, Asmaa Kamal ^{[1
]}

Mohamed, Fathia Korany ^{[1
]}

Soliman, Ahmed Yousef ^{[1
]}

机构：

[1] Fayoum Univ, Fac Sci, Dept Chem, Al Fayyum 63514, Egypt

来源：

HETEROCYCLES | 2018年 / 96卷 / 01期

关键词：

CONVENIENT SYNTHESIS; CYTOTOXIC ACTIVITY; ANTICANCER AGENTS; DERIVATIVES; ANALOGS; DESIGN; SERIES; DYES;

D O I：

10.3987/COM-17-13819

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of coumarin derivatives has been disclosed by allowing 2-aminonicotinonitrile derivative 1 to undergo alkylation, diazotization, and condensation reactions. Moreover, different reagents, such as thiourea, phenyl isothiocyanate, carbon disulfide, ethylenediamine, and hydroxylamine hydrochloride, have been exploited to synthesize more coumarin derivatives, aiming to increase the synthetic potential of coumarin and study the antibacterial activities of the newly synthesized compounds.

引用

页码：50 / 66

页数：17

共 50 条

[41] Novel arylhydrazone derivatives bearing a rhodanine moiety: synthesis and evaluation of their antibacterial activities
Wei Li
Chang-Ji Zheng
Liang-Peng Sun
Ming-Xia Song
Yan Wu
Yin-Jing Li
Yi Liu
Hu-Ri Piao
Archives of Pharmacal Research, 2014, 37 : 852 - 861
[42] Synthesis and antibacterial activity of some coumarin compounds
Desai, P
Champaneri, AC
Desai, KR
ASIAN JOURNAL OF CHEMISTRY, 2000, 12 (04) : 1327 - 1329
[43] Synthesis of diverse novel compounds with anticipated antitumor activities starting with biphenyl chalcone
Ismail, Mahmoud F.
El-sayed, Amira A.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (07) : 2990 - 3001
[44] A Facile Synthesis and Drug Design of Some New Heterocyclic Compounds Incorporating Pyridine Moiety and Their Antimicrobial Evaluation
Abdelrazek, Fathy M.
Gomha, Sobhi M.
Abdelrahman, Aly H.
Metz, Peter
Sayed, Mohsen A.
LETTERS IN DRUG DESIGN & DISCOVERY, 2017, 14 (07) : 752 - 762
[45] Facile Synthesis and Antimicrobial Evaluation of Some New Heterocyclic Compounds Incorporating a Biologically Active Sulfamoyl Moiety
Darwish, Elham S.
SCIENTIFIC WORLD JOURNAL, 2014,
[46] Enaminones as Building Blocks in Heterocyclic Synthesis: Novel Routs for Synthesis of Coumarin Analogs and Study their Anticancer Activities
Sayed, Mariam T.
Elsharbasy, Salwa A.
Abdel-Aziem, Anhar
POLYCYCLIC AROMATIC COMPOUNDS, 2024, 44 (03) : 1581 - 1592
[47] A facile synthesis of some novel thiazoles, arylazothiazoles, and pyrazole linked to thiazolyl coumarin as antibacterial agents
Abdel-Aziem, Anhar
Baaiu, Basma Saad
Elbazzar, Awad Wanis
Elabbar, Fakhri
SYNTHETIC COMMUNICATIONS, 2020, 50 (16) : 2522 - 2530
[48] Synthesis of some new Pyridine-based Heterocyclic Compounds with Anticipated Antitumor Activity
Gomha, Sobhi M.
Abdelrazek, Fathy M.
Abdelrahman, Aly H.
Metz, Peter
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (07) : 1729 - 1737
[49] New Trends of Acetonitrile Moiety in Heterocyclic Synthesis: Synthesis of Some Novel Pyrazole Derivatives as Antibacterial and Antifungal Agents
El-Mekawy, Rasha E.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (04) : 2367 - 2374
[50] Synthesis, crystal structure and evaluation of anticancer activities of some novel heterocyclic compounds based on thymol
Laamari, Yassine
Bimoussa, Abdoullah
Fawzi, Mourad
Oubella, Ali
Rohand, Taoufik
Van Meervelt, Luc
Itto, My Youssef Ait
Morjani, Hamid
Auhmani, Aziz
JOURNAL OF MOLECULAR STRUCTURE, 2023, 1278

← 1 2 3 4 5 →