Novel arylhydrazone derivatives bearing a rhodanine moiety: synthesis and evaluation of their antibacterial activities

被引：0
|
作者：
Wei Li
Chang-Ji Zheng
Liang-Peng Sun
Ming-Xia Song
Yan Wu
Yin-Jing Li
Yi Liu
Hu-Ri Piao
机构：
[1] Yanbian University College of Pharmacy,Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education
来源：
Archives of Pharmacal Research | 2014年 / 37卷
关键词：
Arylhydrazone; Rhodanine; Antibacterial activity; Methicillin-resistant ; Quinolone-resistant ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of arylhydrazone derivatives bearing a rhodanine moiety have been synthesized, characterized, and evaluated as antibacterial agents. Some of these compounds showed potent antibacterial activities against several different strains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIk and IIIk were identified as the most effective, with minimum inhibitory concentration values of 2–4 μg/mL against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcus aureus. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at 64 μg/mL.
引用
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页码：852 / 861
页数：9
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