A FACILE SYNTHESIS OF NOVEL HETEROCYCLIC COMPOUNDS WITH ANTICIPATED ANTIBACTERIAL ACTIVITIES BASED ON COUMARIN MOIETY

被引：9

作者：

Mourad, Asmaa Kamal ^{[1
]}

Mohamed, Fathia Korany ^{[1
]}

Soliman, Ahmed Yousef ^{[1
]}

机构：

[1] Fayoum Univ, Fac Sci, Dept Chem, Al Fayyum 63514, Egypt

来源：

HETEROCYCLES | 2018年 / 96卷 / 01期

关键词：

CONVENIENT SYNTHESIS; CYTOTOXIC ACTIVITY; ANTICANCER AGENTS; DERIVATIVES; ANALOGS; DESIGN; SERIES; DYES;

D O I：

10.3987/COM-17-13819

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel series of coumarin derivatives has been disclosed by allowing 2-aminonicotinonitrile derivative 1 to undergo alkylation, diazotization, and condensation reactions. Moreover, different reagents, such as thiourea, phenyl isothiocyanate, carbon disulfide, ethylenediamine, and hydroxylamine hydrochloride, have been exploited to synthesize more coumarin derivatives, aiming to increase the synthetic potential of coumarin and study the antibacterial activities of the newly synthesized compounds.

引用

页码：50 / 66

页数：17

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