Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread

被引：4

作者：

Czarneski, J

Meyers, J

Peng, T

Agraham, V

Mick, R

Ross, SR

机构：

[1] Univ Penn, Sch Med, Ctr Canc, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Ctr Canc, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 23期

关键词：

D O I：

10.1128/JVI.75.23.11886-11890.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

引用

页码：11886 / 11890

页数：5

共 50 条

[41] STIMULATION OF MOUSE MAMMARY-TUMOR VIRUS SUPERANTIGEN EXPRESSION BY AN INTRAGENIC ENHANCER
REUSS, FU
COFFIN, JM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9293 - 9297
[42] Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox
Jackson, RJ
Ramsay, AJ
Christensen, CD
Beaton, S
Hall, DF
Ramshaw, IA
JOURNAL OF VIROLOGY, 2001, 75 (03) : 1205 - 1210
[43] HDAC Activity Is Required for Efficient Core Promoter Function at the Mouse Mammary Tumor Virus Promoter
Lee, Sang C.
Magklara, Angeliki
Smith, Catharine L.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011,
[44] CHARACTERISTICS OF MAMMARY-TUMOR CULTURES FROM 4 MOUSE STRAINS INFECTED WITH MAMMARY-TUMOR VIRUS
YAGI, MJ
CANCER RESEARCH, 1975, 35 (02) : 370 - 373
[45] Inhibition of murine tumor growth by decitabine is correlated with enhanced expression of the mouse mammary tumor virus
Zhang, Jieyu
Higgins, Savannah
Smith, Riley
Reginald, Tania
Qi, Andrew
Li, Jiayi
King, Anna
Liu, Yingguang
CANCER RESEARCH, 2023, 83 (07)
[46] Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells
Chi, Xiuling
Tai, Hsin-Hsiung
EXPERIMENTAL CELL RESEARCH, 2010, 316 (14) : 2251 - 2259
[47] Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
Y. W. Lee
A. A. Hirani
N. Kyprianou
M. Toborek
Inflammation Research, 2005, 54 : 380 - 389
[48] Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells
Lee, YW
Hirani, AA
Kyprianou, N
Toborek, M
INFLAMMATION RESEARCH, 2005, 54 (09) : 380 - 389
[49] MAMMARY-CANCER STAGES IN BALB/CV MICE - MOUSE MAMMARY-TUMOR VIRUS EXPRESSION AND VIRUS-HOST INTERACTIONS
SLAGLE, BL
MEDINA, D
BUTEL, JS
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1987, 79 (02) : 323 - 335
[50] Mammary gland expression of mouse mammary tumor virus is regulated by a novel element in the long terminal repeat
Qin, W
Golovkina, TV
Peng, T
Nepomnaschy, I
Buggiano, V
Piazzon, I
Ross, SR
JOURNAL OF VIROLOGY, 1999, 73 (01) : 368 - 376

← 1 2 3 4 5 →