Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread

被引：4
|
作者：
Czarneski, J
Meyers, J
Peng, T
Agraham, V
Mick, R
Ross, SR
机构：
[1] Univ Penn, Sch Med, Ctr Canc, Dept Microbiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Ctr Canc, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 23期
关键词：
D O I：
10.1128/JVI.75.23.11886-11890.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.
引用
收藏
页码：11886 / 11890
页数：5
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