Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread

被引：4
|
作者：
Czarneski, J
Meyers, J
Peng, T
Agraham, V
Mick, R
Ross, SR
机构：
[1] Univ Penn, Sch Med, Ctr Canc, Dept Microbiol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Ctr Canc, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 23期
关键词：
D O I：
10.1128/JVI.75.23.11886-11890.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.
引用
收藏
页码：11886 / 11890
页数：5
相关论文
共 50 条
  • [21] The hepatitis B virus X protein up-regulates lymphotoxin α expression in hepatocytes
    Lee, SH
    Park, SG
    Lim, SO
    Jung, G
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2005, 1741 (1-2): : 75 - 84
  • [22] Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection
    Wang, EX
    Albritton, L
    Ross, SR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (15) : 10243 - 10249
  • [23] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TAT GENE UP-REGULATES INTERLEUKIN-4 RECEPTORS ON A HUMAN B-LYMPHOBLASTOID CELL-LINE
    PURI, RK
    AGGARWAL, BB
    CANCER RESEARCH, 1992, 52 (13) : 3787 - 3790
  • [24] SEQUENCE AND EXPRESSION OF THE MOUSE MAMMARY-TUMOR VIRUS ENV GENE
    REDMOND, SMS
    DICKSON, C
    EMBO JOURNAL, 1983, 2 (01): : 125 - 131
  • [25] Mouse mammary tumor virus superantigen expression is reduced by glucocorticoid treatment
    Sepúlveda, VAT
    Berdel, B
    Coffin, JM
    Reuss, FU
    VIROLOGY, 2000, 275 (01) : 98 - 106
  • [26] CD4 expression is important but not essential for infection with exogenous mouse mammary tumor virus
    Ando, Y
    Wajjwalku, W
    Kishihara, K
    Arai, T
    Niimi, N
    Hiromatsu, K
    Morishima, T
    Yoshikai, Y
    IMMUNOBIOLOGY, 1996, 195 (03) : 376 - 384
  • [27] PROLACTIN REGULATION OF MOUSE MAMMARY-TUMOR VIRUS (MMTV) EXPRESSION IN NORMAL MOUSE MAMMARY EPITHELIUM
    MUNOZ, B
    BOLANDER, FF
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1989, 62 (01) : 23 - 29
  • [28] MAMMARY-TUMOR FORMATION AND HORMONAL-CONTROL OF MOUSE MAMMARY-TUMOR VIRUS EXPRESSION
    HYNES, NE
    GRONER, B
    CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, 1982, 101 : 51 - 74
  • [29] Critical role of dendritic cells in mouse mammary tumor virus in vivo infection
    Cecilia Courreges, Maria
    Burzyn, Dalia
    Nepomnaschy, Irene
    Piazzon, Isabel
    Ross, Susan R.
    JOURNAL OF VIROLOGY, 2007, 81 (08) : 3769 - 3777
  • [30] Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression
    Xingang Xu
    Honglei Zhang
    Qi Zhang
    Jie Dong
    Yabing Liang
    Yong Huang
    Hung-Jen Liu
    Dewen Tong
    Virology Journal, 10
12345