Febuxostat methanol solvate

被引：11

作者：

Jiang, Qi-Ying ^{[2
]}

Qian, Jing-Jing ^{[3
]}

Gu, Jian-Ming ^{[1
]}

Tang, Gu-Ping ^{[2
]}

Hu, Xiu-Rong ^{[1
]}

机构：

[1] Zhejiang Univ, Ctr Anal & Measurement, Hangzhou 310028, Zhejiang, Peoples R China

[2] Zhejiang Univ, Inst Chem Biol & Pharmaceut Chem, Hangzhou 310028, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷

关键词：

GOUT; HYPERURICEMIA; EFFICACY;

D O I：

10.1107/S1600536811014905

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound {systematic name: [2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (febuxostat) methanol monosolvate}, C16H16N2O3S center dot CH4O, the benzene and thiazole rings in the febuxostat molecule are twisted at 5.3 (1)degrees. In the crystal structure, intermolecular O-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds link the febuxostat and methanol molecules into helical chains along the 2(1) screw axis.

引用

页码：O1232 / U1414

页数：10

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