Febuxostat methanol solvate

被引：11
|
作者：
Jiang, Qi-Ying [2 ]
Qian, Jing-Jing [3 ]
Gu, Jian-Ming [1 ]
Tang, Gu-Ping [2 ]
Hu, Xiu-Rong [1 ]
机构：
[1] Zhejiang Univ, Ctr Anal & Measurement, Hangzhou 310028, Zhejiang, Peoples R China
[2] Zhejiang Univ, Inst Chem Biol & Pharmaceut Chem, Hangzhou 310028, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷
关键词：
GOUT; HYPERURICEMIA; EFFICACY;
D O I：
10.1107/S1600536811014905
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
In the title compound {systematic name: [2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid (febuxostat) methanol monosolvate}, C16H16N2O3S center dot CH4O, the benzene and thiazole rings in the febuxostat molecule are twisted at 5.3 (1)degrees. In the crystal structure, intermolecular O-H center dot center dot center dot O and O-H center dot center dot center dot N hydrogen bonds link the febuxostat and methanol molecules into helical chains along the 2(1) screw axis.
引用
收藏
页码：O1232 / U1414
页数：10
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