Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors

被引：36
|
作者：
Sivapriya, Kirubakaran
Suguna, Perumal
Banerjee, Arun
Saravanan, Vadivelu
Rao, Desirazu N.
Chandrasekaran, Srinivasan [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
[2] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期
关键词：
thiourea; selenourea; urease inhibition; tetrathiomolybdate; tetraselenotungstate;
D O I：
10.1016/j.bmcl.2007.07.085
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraseleno-tungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6387 / 6391
页数：5
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