Facile and Efficient Synthesis of a New Class of Pyrazolo[1,5-a]Pyrimidine Derivatives Via One-Pot Multicomponent Reactions

被引：0
|
作者：
A. El-Mekabaty
A. M. Hasel
机构：
[1] Mansoura University,Faculty of Science
来源：
Chemistry of Heterocyclic Compounds | 2015年 / 50卷
关键词：
pyrazole; pyrazolo[1,5-; ]pyrimidines; thiazole; triethyl orthoformate; three-component synthesis;
D O I：
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学科分类号：
摘要：
A novel multicomponent synthesis of highly substituted pyrazolo[1,5-a]pyrimidine derivatives starting from simple and readily available reactants is described. Three-component condensation of 4-(thiazol-2-yldiazenyl)-1H-pyrazole-3,5-diamine with triethyl orthoformate and carbonyl compounds or nitriles containing an activated methylene group gave substituted pyrazolo[1,5-a]pyrimidines. An analogous reaction of 4-(thiazol-2-yldiazenyl)-1H-pyrazole-3,5-diamine with ethyl acetoacetate and benzaldehyde in an effective one-pot process furnished ethyl 2-amino-5-methyl-7-phenyl-3-(thiazol-2-yldiazenyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate.
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页码：1608 / 1615
页数：7
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