Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold

被引：3
|
作者：
Zaremba, O. V. [1 ]
Gorobets, N. Yu [2 ]
Kovalenko, S. S. [1 ]
Drushlyak, O. G. [1 ]
Grevtsov, O. Yu [1 ]
Kovalenko, S. M. [1 ]
机构：
[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine
[2] Natl Acad Sci Ukraine, Sci Technol Complex Inst Monocrystals, UA-61001 Kharkov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 06期
关键词：
azolocarboxamidoacetals; 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one; 2,2-dimethoxyethanamine; pyrazole-3-carboxylic acid; pyrazolo[1,5-a]pyrazin-4(5H)-one; one-pot reaction; DERIVATIVES;
D O I：
10.1007/s10593-013-1326-x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel pyrazolo[1,5-a]pyrazine derivatives has been synthesized using a facile one-pot three-step protocol starting from pyrazole-3-carboxylic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]-pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one have been isolated as intermediate compounds.
引用
收藏
页码：915 / 921
页数：7
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