Synthesis of highly rigid phosphine-oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

被引：17

作者：

Qiu, Zhongxuan ^{[1
]}

Sun, Rui ^{[1
]}

Teng, Dawei ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 41期

关键词：

JM-PHOS LIGANDS; CHIRAL LIGANDS; ENANTIOSELECTIVE CATALYSIS; SUBSTITUTION-REACTION; ALLYLATION REACTIONS; PD COMPLEXES; HYDROGENATION; DESIGN; ACIDS; PHOSPHINOARYLOXAZOLINES;

D O I：

10.1039/c8ob02265h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly rigid spiro phosphine-oxazoline ligand skeleton with a spirocarbon stereogenic center was developed from 7-bromo-1-indanone. The catalytic performance of the ligand was demonstrated in palladium-catalyzed asymmetric allylic alkylation. Under optimized conditions, high yields (up to 99%) and enantioselectivities (up to 99.9% ee) were obtained for reactions of 1,3-diphenylallyl acetates and symmetrical 1,3-dicarbonyl substrates.

引用

页码：7717 / 7724

页数：8

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