Synthesis of highly rigid phosphine-oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

被引：17
|
作者：
Qiu, Zhongxuan [1 ]
Sun, Rui [1 ]
Teng, Dawei [1 ]
机构：
[1] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 41期
关键词：
JM-PHOS LIGANDS; CHIRAL LIGANDS; ENANTIOSELECTIVE CATALYSIS; SUBSTITUTION-REACTION; ALLYLATION REACTIONS; PD COMPLEXES; HYDROGENATION; DESIGN; ACIDS; PHOSPHINOARYLOXAZOLINES;
D O I：
10.1039/c8ob02265h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly rigid spiro phosphine-oxazoline ligand skeleton with a spirocarbon stereogenic center was developed from 7-bromo-1-indanone. The catalytic performance of the ligand was demonstrated in palladium-catalyzed asymmetric allylic alkylation. Under optimized conditions, high yields (up to 99%) and enantioselectivities (up to 99.9% ee) were obtained for reactions of 1,3-diphenylallyl acetates and symmetrical 1,3-dicarbonyl substrates.
引用
收藏
页码：7717 / 7724
页数：8
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