New simple chiral phosphine oxazolidine ligands:: Easy synthesis and application in the palladium-catalyzed asymmetric allylic alkylation

被引：15
|
作者：
Braga, AL [1 ]
Sehnem, JA [1 ]
Lüdtke, DS [1 ]
Zeni, G [1 ]
Silveira, CC [1 ]
Marchi, MI [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
来源：
SYNLETT | 2005年 / 08期
关键词：
phosphines; oxazolidines; allylic alkylations;
D O I：
10.1055/s-2005-868475
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New types of chiral phosphine-oxazolidines have been easily synthesized in a straightforward one-pot process starting from optically active aminoalcohols. They were screened in the Pd-catalyzed asymmetric allylic alkylations of 1,3-diphenyl-2-propenyl acetate with dimethylmalonate. The reaction proceeds smoothly in good to excellent yields and excellent stereoselectivity was obtained (up to 97%).
引用
收藏
页码：1331 / 1333
页数：3
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