Chiral Phosphaalkene-Oxazoline Ligands for the Palladium-Catalyzed Asymmetric Allylic Alkylation

被引：42
|
作者：
Dugal-Tessier, Julien [1 ]
Dake, Gregory R. [1 ]
Gates, Derek P. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 20期
基金：
加拿大自然科学与工程研究理事会;
关键词：
BEARING DIPHOSPHINIDENECYCLOBUTENE LIGANDS; HIGHLY-ACTIVE CATALYSTS; ETHYLENE POLYMERIZATION; COORDINATION CHEMISTRY; AZOMETHINE IMINES; TERMINAL ALKYNES; COMPLEXES; HETEROCYCLES; 5,5-DIMETHYL-4-ISO-PROPYLOXAZOLIDIN-2-ONE; PERSPECTIVES;
D O I：
10.1021/ol1020652
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective catalysis in moderate to excellent yields and ee's has been accomplished using a phosphaalkene-based ligand system. Specifically, the palladium-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate using a chiral P(sp(2)),N(sp(2)) ligand proceeds with a variety of malonate nucleophiles in 73-95% yield (79-92% ee).
引用
收藏
页码：4667 / 4669
页数：3
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