Two new iridoid glycosides from the fruit of Gardenia jasminoides

被引：22

作者：

Li, Hai-Bo ^{[1
,2
]}

Ma, Jin-Feng ^{[1
]}

Mei, Yu-Dan ^{[2
]}

Liu, Ling-Xian ^{[1
]}

Cao, Ze-yu ^{[2
]}

Shi, Dan-Feng ^{[1
]}

Yao, Xin-Sheng ^{[1
]}

Yu, Yang ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm & Guangdong Prov, Key Lab Pharmacodynam Constituents TCM & New Drug, Guangzhou, Peoples R China

[2] Jiangsu Kanion Pharmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Gardenia jasminoides; 2 '-O-cis-coumaroylgardoside; 6 '-O-caffeoylioxide; anti-inflammatory; PGE(2); FRUCTUS-GARDENIA; GLUCOSIDES; EXTRACT; INJURY; ELLIS;

D O I：

10.1080/14786419.2020.1775227

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new iridoid glycosides, 2 '-O-cis-coumaroylgardoside (1), and 6 '-O-caffeoylioxide (2), were isolated from the fruit ofGardenia jasminoides. The structures of these compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR) and chemical methods. The anti-inflammatory activities of the isolates were evaluated by measuring their inhibitory effects on PGE(2) production in LPS stimulated RAW 264.7 macrophages, compounds 1 and 2 could reduce PGE(2) levels in LPS-activated RAW 264.7 macrophages with IC50 values of 121.4 and 83.38 mu M, respectively.

引用

页码：186 / 192

页数：7

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