Synthesis of aryl β-N-acetylglucosammdes modified at C-6 as potential antimicrobial agents

被引：2

作者：

Manfrini, Rozangela Magalhaes ^{[1
]}

de Souza Filho, Jose Dias ^{[1
]}

Figueiredo, Rute Cunha ^{[2
]}

D'Angelis, Allison Fabiano ^{[2
]}

Prado, Maria Auxiliadora Fontes ^{[2
]}

De Aguiar Nunan, Elziria ^{[2
]}

Martins, Gabriela Aires ^{[2
]}

Alves, Ricardo Jose ^{[2
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Fac Farm, Dept Prod Farmaceut, BR-31270901 Belo Horizonte, MG, Brazil

来源：

QUIMICA NOVA | 2008年 / 31卷 / 02期

关键词：

N-acetylglucosamine derivatives; antimicrobial activity;

D O I：

10.1590/S0100-40422008000200026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the synthesis of aryl beta-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents. It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of N-acetylglucosamine in fungi and bacteria. None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), it the concentration of 1 mg/mL in agar diffusion assay.

引用

页码：326 / 329

页数：4

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