General and Green Synthesis of C-6 Sulfonylmethyl 4-Aryl-3,4-dihydropyrimidinones in Water

被引：10
|
作者：
Quan, Zheng-Jun [1 ]
Wei, Qiang-Bing [1 ]
Ma, Dong-Dong [1 ]
Da, Yu-Xia [1 ]
Wang, Xi-Cun [1 ]
Shen, Mao-Sen [2 ]
机构：
[1] NW Normal Univ, Coll Chem & Chem Engn, Gansu Key Lab Polymer Mat, Lanzhou 730070, Gansu, Peoples R China
[2] Jing Tai Second Middle Sch, Baiyin, Gansu, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 12期
关键词：
Bromination; 3; 4-dihydropyrimidinones (DHPMs); dioxane dibromide; water; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; AMMONIUM TRIBROMIDE OATB; ORGANIC-REACTIONS; AQUEOUS-MEDIA; RECEPTOR ANTAGONISTS; MICROWAVE; HETEROCYCLES; CONVENIENT; BLOCKERS; POTENT;
D O I：
10.1080/00397910802654682
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, inexpensive, and green reaction permitting the synthesis of new C-6 arylsulfonylmethyl 4-aryl-3,4-dihydropyrimidinones in water by S-alkylation of 6-bromomethyl 3,4-dihydropyrimidinones 2 with benzenesulfinic acid anions 3 is reported. The required 6-bromomethyldihydropyrimidone precursors 2 were readily prepared using an organic solid brominating reagent.
引用
收藏
页码：2230 / 2239
页数：10
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