Identification and characterization of three novel HLA alleles, HLA-A*240214, HLA-A*3215 and HLA-DQB1*060302

被引：2
|
作者：
Heinold, A.
Bauer, M.
Opelz, G.
Scherer, S.
Schmidt, A. H.
Tran, T. H.
机构：
[1] Univ Heidelberg, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
[2] DKMS German Bone Marrow Donor Ctr, Tubingen, Germany
来源：
TISSUE ANTIGENS | 2007年 / 70卷 / 06期
关键词：
HLA-A*240214; HLA-A*3215; HLA-DQB1*060302; human leukocyte antigen; intergenic recombination; sequence-based typing;
D O I：
10.1111/j.1399-0039.2007.00958.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We describe three novel human leukocyte antigen (HLA) alleles found in three different Caucasians, HLA-A*240214, HLA-A*3215 and HLA-DQB1*060302. As compared with HLA-A*24020101, HLA-A*240214 has a synonymous nucleotide (nt) exchange in codon 132. HLA-A*240214 may have arisen from intergenic recombination between HLA-A*24020101 and an HLA-B or HLA-C allele. The second novel allele, HLA-A*3215, has three nucleotide exchanges as compared with HLA-A*320101. These variations result in amino acid exchanges in codons 62 and 63, generating the public epitope of the serological HLA-A10 group. The third novel allele, HLA-DQB1*060302, has one synonymous nucleotide exchange within codon 38 as compared with HLA-DQB1*060301. In a family segregation study, we found that HLA-DQB1*060302, similar to the known HLA-DQB1*060301 allele, cosegregates with HLA-DRB1*1301.
引用
收藏
页码：511 / 514
页数：4
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