Identification and characterization of three novel HLA alleles, HLA-A*240214, HLA-A*3215 and HLA-DQB1*060302

被引：2
|
作者：
Heinold, A.
Bauer, M.
Opelz, G.
Scherer, S.
Schmidt, A. H.
Tran, T. H.
机构：
[1] Univ Heidelberg, Inst Immunol, Dept Transplantat Immunol, D-69120 Heidelberg, Germany
[2] DKMS German Bone Marrow Donor Ctr, Tubingen, Germany
来源：
TISSUE ANTIGENS | 2007年 / 70卷 / 06期
关键词：
HLA-A*240214; HLA-A*3215; HLA-DQB1*060302; human leukocyte antigen; intergenic recombination; sequence-based typing;
D O I：
10.1111/j.1399-0039.2007.00958.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We describe three novel human leukocyte antigen (HLA) alleles found in three different Caucasians, HLA-A*240214, HLA-A*3215 and HLA-DQB1*060302. As compared with HLA-A*24020101, HLA-A*240214 has a synonymous nucleotide (nt) exchange in codon 132. HLA-A*240214 may have arisen from intergenic recombination between HLA-A*24020101 and an HLA-B or HLA-C allele. The second novel allele, HLA-A*3215, has three nucleotide exchanges as compared with HLA-A*320101. These variations result in amino acid exchanges in codons 62 and 63, generating the public epitope of the serological HLA-A10 group. The third novel allele, HLA-DQB1*060302, has one synonymous nucleotide exchange within codon 38 as compared with HLA-DQB1*060301. In a family segregation study, we found that HLA-DQB1*060302, similar to the known HLA-DQB1*060301 allele, cosegregates with HLA-DRB1*1301.
引用
收藏
页码：511 / 514
页数：4
相关论文
共 50 条
  • [41] Identification of a novel HLA-A allele, HLA-A*02:590, in a Korean individual
    Lee, E. Jin
    Kim, M.
    Jung, Y. -A.
    Lee, H.
    Lee, Y. K.
    HLA, 2016, 87 (06) : 454 - U90
  • [42] Identification of a novel HLA-A allele, HLA-A*01:195, in a UAE national
    Abdrabou, Wael
    Witzel, Ini-Isabee
    Paduch, Agnieszka
    Tay, Guan
    Alsafar, Habiba
    HUMAN IMMUNOLOGY, 2016, 77 (07) : 605 - 608
  • [43] IDENTIFICATION OF AN ANTIBODY TO HLA-A*02 ALLELES IN A PATIENT WHO TYPES FOR HLA-A*02:02
    Helman, Sandra W.
    HUMAN IMMUNOLOGY, 2011, 72 : S38 - S38
  • [44] DESCRIPTION OF THREE NOVEL ALLELES HLA-DQB1*05:48, HLA-DQB1*06:126, AND HLA-DQB1*06:123 IN SAUDI STEM CELL DONORS.
    Fakhoury, Hana
    Jawdat, Dunia
    Alaskar, Ahmed
    Aljumah, Mohammed
    Hajeer, Ali H.
    HUMAN IMMUNOLOGY, 2014, 75 : 99 - 99
  • [45] A novel HLA-A*03 allele, HLA-A*03:71
    Yu, M.
    Hall, J. E.
    Hartman, K.
    Czech, J.
    Jennings, L.
    TISSUE ANTIGENS, 2010, 76 (04): : 331 - 331
  • [46] Novel HLA-A, HLA-B, and HLA-DRB1 alleles identified in Brazilian individuals
    Tavares, Jessica
    Petry, Natalia A.
    da Silva, Jose Samuel
    Bicalho, Maria da Graca
    de Araujo-Souza, Patricia Savio
    HLA, 2022, 99 (01) : 31 - 32
  • [47] HLA-A*02:513, a novel HLA-A*02 allele
    Pei, Y. F.
    Huang, H. N.
    Li, H. C.
    Shen, W. D.
    HLA, 2016, 87 (05) : 382 - 383
  • [48] A novel HLA-A*02 allele, HLA-A*02:129
    Zhang, K. Y.
    Zhang, Z. X.
    Wang, L. J.
    Liu, N.
    Shan, X. Y.
    TISSUE ANTIGENS, 2013, 81 (06): : 450 - 451
  • [49] Characterization of a novel HLA-DQB1*05 allele, HLA-DQB1*05:03:09
    Li, X.
    Zou, H.
    Li, M.
    Zuo, Y.
    Chen, Q.
    TISSUE ANTIGENS, 2014, 83 (05): : 367 - U68
  • [50] Characterization of a novel HLA-DQB1*06 allele, HLA-DQB1*06:04:04
    Cosentini, E.
    Andreani, M.
    Ciardiello, G.
    Di Luzio, A.
    Testi, M.
    TISSUE ANTIGENS, 2013, 82 (01): : 73 - 74
12345