Benzyl 2-{[2-(tert-butoxycarbonylamino)-4-methylpentanoyl]methylamino}-4-methylpentanoate

被引:7
|
作者
Liao, Xiao-Jian
Xu, Wen-Jie
Xu, Shi-Hai [1 ]
Dong, Fang-Fang
机构
[1] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China
[2] Jinan Univ, Inst Hydrobiol, Guangzhou 510632, Guangdong, Peoples R China
关键词
D O I
10.1107/S1600536807029418
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The title compound, C25H40N2O5, was synthesized in 55.9% yield by condensation of N-methyl-L-leucine benzyl ester toluene sulfonic acid with tert-butoxycarbonyl-L-leucine at 273 K and its crystal structure determined. The dipeptide derivative conjugates through the amide linkage and includes two protecting groups, a tert-butyloxycarbonyl group at the C-tip and a benzyl group at the N-tip.
引用
收藏
页码:O3313 / U4398
页数:10
相关论文
共 50 条
  • [1] 2-[(tert-Butoxycarbonylamino)oxy]acetic acid
    Zhang, Jing-Yu
    Tong, Yan
    Wang, Shengqi
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2324 - U153
  • [2] 2-(tert-Butoxycarbonylamino)-2-(2-fluorophenyl)acetic acid
    Anwar, Muhammad Mahmood
    Iqbal, Muhammad Saeed
    Tahir, M. Nawaz
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2891 - U2108
  • [3] (R)-Methyl 2-(furan-2-carboxamido)-4-methylpentanoate
    Xu, Wen-Jie
    Liao, Xiao-Jian
    Xu, Shi-Hai
    Liu, Po-Run
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O3644 - U4776
  • [4] Methyl 2-[2-(tert-butoxycarbonylamino)-1,3-benzothiazole-6-carboxamido]acetate
    Gao, Dan
    Fang, Xing
    Yu, Hai-Yang
    Wang, Jun-Dong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2012, 68
  • [5] (S)-(Z)-Methyl 2-[2,3-bis(benzyloxycarbonyl)guanidino]-4-methylpentanoate
    Fronczek, Chris F.
    Kil, HyunJoo
    McLaughlin, Mark L.
    Fronczek, Frank R.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O27 - U1540
  • [6] Ethyl 2-(tert-butoxycarbonylamino)-1,3-benzothiazole-6-carboxylate
    Lei, Can
    Fang, Xin
    Yu, Hai-Yang
    Huang, Ming-Dong
    Wang, Jun-Dong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O914 - U3003
  • [7] Methyl 2-(tert-butoxycarbonylamino)-1,3-thiazole-5-carboxylate
    An, Kang
    Guan, Jiannin
    Yu, Pen
    Yang, Hao
    Wan, Rong
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2343 - U616
  • [8] Enantioselective Synthesis of Benzyl (1S,2R,4R)-4-(tert-Butoxycarbonylamino)-2-(hydroxymethyl)cyclohexylcarbamate Using an Iodolactamization As the Key Step
    Campbell, Carlton L.
    Hassler, Carla
    Ko, Soo S.
    Voss, Matthew E.
    Guaciaro, Michael A.
    Carter, Percy H.
    Cherney, Robert J.
    JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (16): : 6368 - 6370
  • [9] (S)-O-succinimidyl N-[2-(tert-butoxycarbonylamino)propyl]carbamate
    Menschise, V
    Didierjean, C
    Semetey, V
    Guichard, G
    Briand, JP
    Aubry, A
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2001, 57 : o222 - o224
  • [10] (S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate
    Lentini, Giovanni
    Cavalluzzi, Maria Maddalena
    Degennaro, Leonardo
    Fracchiolla, Giuseppe
    Perna, Filippo
    Scilimati, Antonio
    MOLBANK, 2019, (01)