Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

被引：44
|
作者：
Radonjic-Hoesli, Susanne [1 ]
Valent, Peter [2 ]
Klion, Amy D. [3 ]
Wechsler, Michael E. [4 ]
Simon, Hans-Uwe [1 ]
机构：
[1] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland
[2] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, A-1090 Vienna, Austria
[3] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
[4] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷
基金：
奥地利科学基金会;
关键词：
tyrosine kinase inhibitors; biologicals; asthma; chronic eosinophilic leukemia; hypereosinophilic syndrome; LEUKEMIA STEM-CELLS; THYMIC STROMAL LYMPHOPOIETIN; CRTH2 ANTAGONIST OC000459; DUAL IL-4/IL-13 ANTAGONIST; TYROSINE KINASE INHIBITOR; GROWTH-FACTOR RECEPTOR; HYPEREOSINOPHILIC SYNDROME; PHILADELPHIA-CHROMOSOME; LYMPHOCYTE FUNCTION; PROSTAGLANDIN D-2;
D O I：
10.1146/annurev-pharmtox-010814-124407
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.
引用
收藏
页码：633 / 656
页数：24
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