Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

被引：44

作者：

Radonjic-Hoesli, Susanne ^{[1
]}

Valent, Peter ^{[2
]}

Klion, Amy D. ^{[3
]}

Wechsler, Michael E. ^{[4
]}

Simon, Hans-Uwe ^{[1
]}

机构：

[1] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland

[2] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, A-1090 Vienna, Austria

[3] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[4] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷

基金：

奥地利科学基金会;

关键词：

tyrosine kinase inhibitors; biologicals; asthma; chronic eosinophilic leukemia; hypereosinophilic syndrome; LEUKEMIA STEM-CELLS; THYMIC STROMAL LYMPHOPOIETIN; CRTH2 ANTAGONIST OC000459; DUAL IL-4/IL-13 ANTAGONIST; TYROSINE KINASE INHIBITOR; GROWTH-FACTOR RECEPTOR; HYPEREOSINOPHILIC SYNDROME; PHILADELPHIA-CHROMOSOME; LYMPHOCYTE FUNCTION; PROSTAGLANDIN D-2;

D O I：

10.1146/annurev-pharmtox-010814-124407

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.

引用

页码：633 / 656

页数：24

共 50 条

[21] Siglecs as potential targets of therapy in human mast cell- and/or eosinophil-associated diseases
O'Sullivan, Jeremy A.
Youngblood, Bradford A.
Schleimer, Robert P.
Bochner, Bruce S.
SEMINARS IN IMMUNOLOGY, 2023, 69
[22] Eosinophil-associated Ribonuclease 11 Is a Macrophage Chemoattractant
Yamada, Kelsey J.
Barker, Tolga
Dyer, Kimberly D.
Rice, Tyler A.
Percopo, Caroline M.
Garcia-Crespo, Katia E.
Cho, Soochin
Lee, James J.
Druey, Kirk M.
Rosenberg, Helene F.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (14) : 8863 - 8875
[23] Eosinophil-Associated Gastrointestinal Manifestations During OIT
Goldberg, Michael R.
Epstein-Rigbi, Naama
Elizur, Arnon
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2023, 65 (03) : 365 - 376
[24] Eosinophil-Associated Gastrointestinal Disorders with Asthma: Immunohistochemical Analyses
Shirai, Toshihiro
Komiyama, Akira
Hayakawa, Hiroshi
Hashimoto, Dai
Suda, Takafumi
Chida, Kingo
INTERNAL MEDICINE, 2009, 48 (15) : 1315 - 1321
[25] Cardiopulmonary and Gastrointestinal Manifestations of Eosinophil-associated Diseases and Idiopathic Hypereosinophilic Syndromes: Multimodality Imaging Approach
Katre, Rashmi S.
Sunnapwar, Abhijit
Restrepo, Carlos S.
Katabathina, Venkata S.
Mumbower, Amy
Baxi, Ameya
Sonavane, Sushilkumar
RADIOGRAPHICS, 2016, 36 (02) : 433 - 451
[26] Mepolizumab for Eosinophil-Associated COPD: Analysis of METREX and METREO
Pavord, Ian D.
Chapman, Kenneth R.
Bafadhel, Mona
Sciurba, Frank C.
Bradford, Eric S.
Harris, Stephanie Schweiker
Mayer, Bhabita
Rubin, David B.
Yancey, Steven W.
Paggiaro, Pierluigi
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2021, 16 : 1755 - 1770
[27] Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)
Bochner, Bruce S.
Book, Wendy
Busse, William W.
Butterfield, Joseph
Furuta, Glenn T.
Gleich, Gerald J.
Klion, Amy D.
Lee, James J.
Leiferman, Kristin M.
Minnicozzi, Michael
Moqbel, Redwan
Rothenberg, Marc E.
Schwartz, Lawrence B.
Simon, Hans-Uwe
Wechsler, Michael E.
Weller, Peter F.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (03) : 587 - 596
[28] Identification of cDNA encoding rat eosinophil cationic protein/eosinophil-associated ribonuclease
Nittoh, T
Hirakata, M
Mue, S
Ohuchi, K
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1997, 1351 (1-2): : 42 - 46
[29] Eosinophil-Associated Genes are Potential Biomarkers for Hepatocellular Carcinoma Prognosis
Wang, Qinghao
Zhang, Zixin
Zhou, Hao
Qin, Yanling
He, Jun
Li, Limin
Ding, Xiaofeng
JOURNAL OF CANCER, 2024, 15 (17): : 5605 - 5621
[30] Eosinophils and eosinophil-associated disorders: immunological, clinical, and molecular complexity
Valent, Peter
Degenfeld-Schonburg, Lina
Sadovnik, Irina
Horny, Hans-Peter
Arock, Michel
Simon, Hans-Uwe
Reiter, Andreas
Bochner, Bruce S.
SEMINARS IN IMMUNOPATHOLOGY, 2021, 43 (03) : 423 - 438

← 1 2 3 4 5 →