Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy

被引：44

作者：

Radonjic-Hoesli, Susanne ^{[1
]}

Valent, Peter ^{[2
]}

Klion, Amy D. ^{[3
]}

Wechsler, Michael E. ^{[4
]}

Simon, Hans-Uwe ^{[1
]}

机构：

[1] Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland

[2] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, A-1090 Vienna, Austria

[3] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[4] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷

基金：

奥地利科学基金会;

关键词：

tyrosine kinase inhibitors; biologicals; asthma; chronic eosinophilic leukemia; hypereosinophilic syndrome; LEUKEMIA STEM-CELLS; THYMIC STROMAL LYMPHOPOIETIN; CRTH2 ANTAGONIST OC000459; DUAL IL-4/IL-13 ANTAGONIST; TYROSINE KINASE INHIBITOR; GROWTH-FACTOR RECEPTOR; HYPEREOSINOPHILIC SYNDROME; PHILADELPHIA-CHROMOSOME; LYMPHOCYTE FUNCTION; PROSTAGLANDIN D-2;

D O I：

10.1146/annurev-pharmtox-010814-124407

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well as new strategies and drug targets relevant to both primary and secondary eosinophilic diseases, including allergic disorders.

引用

页码：633 / 656

页数：24

共 50 条

[1] Allergy and eosinophil-associated gastrointestinal disorders (EGID)
DeBrosse, Charles W.
Rothenberg, Marc E.
CURRENT OPINION IN IMMUNOLOGY, 2008, 20 (06) : 703 - 708
[2] Eosinophils and eosinophil-associated diseases: An update
O'Sullivan, Jeremy A.
Bochner, Bruce S.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018, 141 (02) : 505 - 517
[3] Experimental analysis of eosinophil-associated gastrointestinal diseases
Hogan, Simon P.
Foster, Paul S.
Rothenberg, Marc E.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 2 (03) : 239 - 248
[4] Improving Care in Eosinophil-Associated Diseases: A Charter
David J. Jackson
Praveen Akuthota
Rebeca Andradas
Albert J. Bredenoord
Amanda Cordell
Sarah Gray
Joyce Kullman
Sameer K. Mathur
Ian Pavord
Florence Roufosse
Christian Rubio
Irena Clisson Rusek
Dagmar Simon
Mary Jo Strobel
Tonya Winders
Advances in Therapy, 2022, 39 : 2323 - 2341
[5] Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases
Stone, K. D.
Prussin, C.
CLINICAL AND EXPERIMENTAL ALLERGY, 2008, 38 (12): : 1858 - 1865
[6] Eosinophil-associated disorders
不详
NATURE REVIEWS DRUG DISCOVERY, 2013, 12 (02) : 95 - 95
[7] Improving Care in Eosinophil-Associated Diseases: A Charter COMMENT
Jackson, David J.
Akuthota, Praveen
Andradas, Rebeca
Bredenoord, Albert J.
Cordell, Amanda
Gray, Sarah
Kullman, Joyce
Mathur, Sameer K.
Pavord, Ian
Roufosse, Florence
Rubio, Christian
Rusek, Irena Clisson
Simon, Dagmar
Strobel, Mary Jo
Winders, Tonya
ADVANCES IN THERAPY, 2022, 39 (06) : 2323 - 2341
[8] Management of eosinophil-associated inflammatory diseases: the importance of a multidisciplinary approach
Quirce, Santiago
Cosio, Borja G.
Espana, Agustin
Blanco, Ricardo
Mullol, Joaquim
Santander, Cecilio
del Pozo, Victoria
FRONTIERS IN IMMUNOLOGY, 2023, 14
[9] Eosinophil function in eosinophil-associated gastrointestinal disorders
Hogan, Simon P.
Rothenberg, Marc E.
CURRENT ALLERGY AND ASTHMA REPORTS, 2006, 6 (01) : 65 - 71
[10] Mechanisms of eosinophil-associated inflammation
Gleich, GJ
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (04) : 651 - 663

← 1 2 3 4 5 →