Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives

被引：45
|
作者：
Patel, Mehul M. [1 ]
Mali, Mimansha D. [1 ]
Patel, Saurabh K. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Chem Res Lab, Dept Chem, Surat 395007, Gujarat, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 21期
关键词：
4-(Acridin-9-ylmethyl)-2H-(substituted chromen)-2-one; Antibacterial activity; Antifungal activity; Anticancer activity;
D O I：
10.1016/j.bmcl.2010.06.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram (+)ve), Escherichia coli, Pseudomonas aeruginosa (gram -ve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC50 values in the low micromolar range. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：6324 / 6326
页数：3
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