The Zebrafish Neurophenome Database (ZND): A Dynamic Open-Access Resource for Zebrafish Neurophenotypic Data

被引:13
|
作者
Kyzar, Evan [1 ,2 ]
Zapolsky, Ivan [1 ,2 ]
Green, Jeremy [1 ,2 ]
Gaikwad, Siddharth [1 ,2 ]
Pham, Mimi [1 ,2 ]
Collins, Christopher [1 ,2 ]
Roth, Andrew [1 ,2 ]
Stewart, Adam Michael [1 ,2 ]
St-Pierre, Paul [3 ,4 ]
Hirons, Budd [3 ,4 ]
Kalueff, Allan V. [1 ,2 ]
机构
[1] Tulane Univ, Sch Med, Dept Pharmacol, ZNRC, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Neurosci Program, ZNRC, New Orleans, LA 70112 USA
[3] Tulane Innovat Learning Ctr, New Orleans, LA USA
[4] Howard Tilton Mem Lib, New Orleans, LA USA
关键词
ONLINE MENDELIAN INHERITANCE; INFORMATION NETWORK ZFIN; ANXIETY-LIKE BEHAVIOR; MODEL ORGANISM; ADULT ZEBRAFISH; DRUG DISCOVERY; GENOME PROJECT; HUMAN-DISEASE; OMICS DATA; KNOWLEDGEBASE;
D O I
10.1089/zeb.2011.0725
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Zebrafish (Danio rerio) are widely used in neuroscience research, where their utility as a model organism is rapidly expanding. Low cost, ease of experimental manipulations, and sufficient behavioral complexity make zebrafish a valuable tool for high-throughput studies in biomedicine. To complement the available repositories for zebrafish genetic information, there is a growing need for the collection of zebrafish neurobehavioral and neurological phenotypes. For this, we are establishing the Zebrafish Neurophenome Database (ZND; www.tulane.edu/similar to znpindex/similar to search) as a new dynamic online open-access data repository for behavioral and related physiological data. ZND, currently focusing on adult zebrafish, combines zebrafish neurophenotypic data with a simple, easily searchable user interface, which allow scientists to view and compare results obtained by other laboratories using various treatments in different testing paradigms. As a developing community effort, ZND is expected to foster innovative research using zebrafish by federating the growing body of zebrafish neurophenotypic data.
引用
收藏
页码:8 / 14
页数:7
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