Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol

被引：47

作者：

Shahrisa, Aziz ^{[1
]}

Teimuri-Mofrad, Reza ^{[1
]}

Gholamhosseini-Nazari, Mahdi ^{[1
]}

机构：

[1] Univ Tabriz, Dept Organ & Biochem, Fac Chem, Tabriz 5166614766, Iran

来源：

MOLECULAR DIVERSITY | 2015年 / 19卷 / 01期

关键词：

1-Aminoalkyl-2-naphthol; Betti base; Organocatalyst; Solvent-free reaction; One-pot; N; N-dimethylethanolamine; MCRs; RECYCLABLE HETEROGENEOUS CATALYST; RAPID SYNTHESIS; AMIDOALKYL NAPHTHOLS; ACID; 1-AMIDOALKYL-2-NAPHTHOLS; AMINONAPHTHOLS; CONVENIENT; MILD; ORGANOCATALYST; DERIVATIVES;

D O I：

10.1007/s11030-014-9559-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A variety of organocatalysts has been screened for the synthesis of arylaminonaphthols. It has been shown that (N,N-dimethylethanolamine) is a highly efficient organocatalyst for the direct synthesis of a novel class of arylaminonaphthols via three-component condensation of 2-naphthol, aldehydes, and arylamines under solvent-free conditions. Mild, one-pot, and green reaction conditions, relatively short reaction times and good yields make this protocol highly significant. 25 new compounds have been synthesized by this method.

引用

页码：87 / 101

页数：15

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