Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol

被引：47
|
作者：
Shahrisa, Aziz [1 ]
Teimuri-Mofrad, Reza [1 ]
Gholamhosseini-Nazari, Mahdi [1 ]
机构：
[1] Univ Tabriz, Dept Organ & Biochem, Fac Chem, Tabriz 5166614766, Iran
来源：
MOLECULAR DIVERSITY | 2015年 / 19卷 / 01期
关键词：
1-Aminoalkyl-2-naphthol; Betti base; Organocatalyst; Solvent-free reaction; One-pot; N; N-dimethylethanolamine; MCRs; RECYCLABLE HETEROGENEOUS CATALYST; RAPID SYNTHESIS; AMIDOALKYL NAPHTHOLS; ACID; 1-AMIDOALKYL-2-NAPHTHOLS; AMINONAPHTHOLS; CONVENIENT; MILD; ORGANOCATALYST; DERIVATIVES;
D O I：
10.1007/s11030-014-9559-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A variety of organocatalysts has been screened for the synthesis of arylaminonaphthols. It has been shown that (N,N-dimethylethanolamine) is a highly efficient organocatalyst for the direct synthesis of a novel class of arylaminonaphthols via three-component condensation of 2-naphthol, aldehydes, and arylamines under solvent-free conditions. Mild, one-pot, and green reaction conditions, relatively short reaction times and good yields make this protocol highly significant. 25 new compounds have been synthesized by this method.
引用
收藏
页码：87 / 101
页数：15
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