Nickel (II) chloride hexahydrate as an efficient catalyst for the preparation of highly functionalised piperidine derivatives

被引：14

作者：

Shafiee, Mohammad Reza Mohammad ^{[1
]}

Najafabadi, Batool Hojati ^{[1
]}

Ghashang, Majid ^{[1
]}

机构：

[1] Islamic Azad Univ, Najafabad Branch, Fac Sci, Dept Chem, Esfahan, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2012年 / 06期

关键词：

NiCl2 center dot 6H(2)O; highly functionalised piperidines; aldehydes; amine; acetoacetic esters; ONE-POT SYNTHESIS; ECONOMIC PASE SYNTHESIS; ATOM; SCAFFOLDS;

D O I：

10.3184/174751912X13351985240633

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nickel (II) chloride hexahydrate (NiCl2 center dot 6H(2)O) has been employed for the efficient synthesis of highly functionalised piperidines via three-component cyclo-condensation reaction of aldehydes, aromatic amines and acetoacetic esters in ethanol under ambient condition. The key advantages of this procedure are high yields, easy work-up and purification of products by non-chromatographic methods.

引用

页码：336 / 339

页数：4

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