Nickel (II) chloride hexahydrate as an efficient catalyst for the preparation of highly functionalised piperidine derivatives

被引：14
|
作者：
Shafiee, Mohammad Reza Mohammad [1 ]
Najafabadi, Batool Hojati [1 ]
Ghashang, Majid [1 ]
机构：
[1] Islamic Azad Univ, Najafabad Branch, Fac Sci, Dept Chem, Esfahan, Iran
来源：
JOURNAL OF CHEMICAL RESEARCH | 2012年 / 06期
关键词：
NiCl2 center dot 6H(2)O; highly functionalised piperidines; aldehydes; amine; acetoacetic esters; ONE-POT SYNTHESIS; ECONOMIC PASE SYNTHESIS; ATOM; SCAFFOLDS;
D O I：
10.3184/174751912X13351985240633
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nickel (II) chloride hexahydrate (NiCl2 center dot 6H(2)O) has been employed for the efficient synthesis of highly functionalised piperidines via three-component cyclo-condensation reaction of aldehydes, aromatic amines and acetoacetic esters in ethanol under ambient condition. The key advantages of this procedure are high yields, easy work-up and purification of products by non-chromatographic methods.
引用
收藏
页码：336 / 339
页数：4
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