Highly Efficient Nickel(II) Chloride/Bis(tricyclohexylphosphine)nickel(II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride

被引：44
|
作者：
Zhao, Wenwen [1 ]
Wu, Jingjing [1 ]
Cao, Song [1 ]
机构：
[1] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 04期
基金：
中国国家自然科学基金;
关键词：
cocatalysts; fluorides; hydrodefluorination; lithium triethylborohydride; nickel catalysts; reduction; C-F BONDS; GEM-DIFLUOROMETHYLENE DERIVATIVES; LITHIUM ALUMINUM-HYDRIDE; METAL-COMPLEXES; ACTIVATION; PENTAFLUOROPYRIDINE; CP-ASTERISK-2ZRH2; DEFLUORINATION; MECHANISM; CATALYSIS;
D O I：
10.1002/adsc.201100783
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A simple and highly efficient approach for the hydrodefluorination of both fluoroarenes and trifluorotoluenes in the presence of lithium triethylborohydride using a catalytic amount of nickel(II) chloride (NiCl2, 2 mol%) combined with a catalytic amount of bis(tricyclohexylphosphine)nickel(II) chloride [NiCl2(PCy3)2, 2 mol%] as cocatalyst has been developed.
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页码：574 / 578
页数：5
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