A novel NF-κB activation inhibitor blocks inflammatory mediator production and disease severity in the dextran sulfate (DSS) model of mouse colitis

被引:0
|
作者
Roshak, A
Flanigan, A
Imburgia, C
Carlson, K
Marshall, LA
Callahan, J
Murthy, S
Yonchuk, J
机构
[1] GlaxoSmithKline, King Of Prussia, PA USA
[2] Med Coll Penn & Hahnemann Univ, Philadelphia, PA USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
3729
引用
收藏
页码:A690 / A690
页数:1
相关论文
共 50 条
  • [41] Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression
    Shah, Yatrik M.
    Ma, Xiaochao
    Morimura, Keiichirou
    Kim, Insook
    Gonzalez, Frank J.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 292 (04): : G1114 - G1122
  • [42] An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice
    J. F. MacMaster
    D. M. Dambach
    D. B. Lee
    K. K. Berry
    Y. Qiu
    F. C. Zusi
    J. R. Burke
    Inflammation Research, 2003, 52 : 508 - 511
  • [43] An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice
    MacMaster, JF
    Dambach, DM
    Lee, DB
    Berry, KK
    Qiu, Y
    Zusi, FC
    Burke, JR
    INFLAMMATION RESEARCH, 2003, 52 (12) : 508 - 511
  • [44] Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    Ghosh, Anamitra
    Roy, Avik
    Liu, Xiaojuan
    Kordower, Jeffrey H.
    Mufson, Elliott J.
    Hartley, Dean M.
    Ghosh, Sankar
    Mosley, R. Lee
    Gendelman, Howard E.
    Pahan, Kalipada
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) : 18754 - 18759
  • [45] NF-κB Activation Precedes Increases in mRNA Encoding Neurokinin-1 Receptor, Proinflammatory Cytokines, and Adhesion Molecules in Dextran Sulfate Sodium–Induced Colitis in Rats
    Karen L. Reed
    A. Brent Fruin
    Adam C. Gower
    Kelly D. Gonzales
    Arthur F. Stucchi
    Christopher D. Andry
    Michael O'brien
    James M Becker
    Digestive Diseases and Sciences, 2005, 50 : 2366 - 2378
  • [46] Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF-κB Pathway
    Ge, Wei
    Zhou, Bu-Gao
    Zhong, You-Bao
    Liu, Su-Qing
    Huang, Jia-Qi
    Yuan, Wang-Yuan
    Xie, Chang-Ying
    Liu, Duan-Yong
    Wang, Hai-Yan
    Zuo, Zheng-Yun
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [47] SP-333, a Proteolysis-resistant Agonist of Guanylate Cyclase-C, Inhibits Activation of NF-κB and Suppresses Production of Inflammatory Cytokines to Ameliorate DSS-induced Colitis in Mice
    Zhang, Graham
    Arjunan, Krishna Priya
    Foss, John
    Comiskey, Stephen
    Shailubhai, Kunwar
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 : S626 - S626
  • [48] INHIBITION OF LEUKOTRIENE BIOSYNTHESIS, CYTOKINE PRODUCTION AND DISEASE SEVERITY IN DEXTRAN SULFATE-MEDIATED COLITIS IN THE MOUSE BY SK-AND-F 107649, A SELECTIVE 5-LIPOXYGENASE (5-LO) INHIBITOR
    MURTHY, SN
    MURTHY, N
    GRISWOLD, DE
    HILLEGAS, LM
    WEBB, EF
    GASTROENTEROLOGY, 1994, 106 (04) : A741 - A741
  • [49] The role of the complement and contact systems in the dextran sulfate sodium-induced colitis model: the effect of C1 inhibitor in inflammatory bowel disease
    Lu, Fengxin
    Fernandes, Stacey M.
    Davis, Alvin E., III
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2010, 298 (06): : G878 - G883
  • [50] Cinnamaldehyde Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulating TLR4/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation
    Tan, Xiaofen
    Wen, Yifan
    Han, Zhijun
    Su, Xuyang
    Peng, Jing
    Chen, Feng
    Wang, Yadong
    Wang, Tianming
    Wang, Changzhong
    Ma, Kelong
    CHEMISTRY & BIODIVERSITY, 2023, 20 (02)